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Gonalves PB, Romeiro NC (2019) Multi-target natural products as alternatives against oxidative stress in chronic obstructive pulmonary disease (COPD)

Stockwell BR, Friedmann Angeli JP, Bayir H et al (2017) Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease

At the same time, more recent reviews emphasise that preclinical data predominate, so interpretation of the results should take into account the experimental nature of the substance and the limited number of high-quality clinical data

This effect is attributed to PCs dose-dependently enhancing GSK-3 phosphorylation, attenuating caspase-3 activation, and inhibiting lactic acid adhesion protein expression, thereby mitigating oxidative stress and apoptosis induced by AGEs in HUVECs

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